-- 'here he has not gone so far as to trouble the eternal gods or the stars that blight our human lot.' That comes in Star Maker. Here the 18th and last men are trapped in our solar system when final doom reaches out from the stars. Next -- Star Maker, which makes this book seem parochial.
'Star Maker', a sort of a sequel (yes, you can have a sequel to the end of mankind!) manages to trump 'Last and First Men' (an amazing feat) and is possibly an even better book but if you want to read either of these you should start with 'Last and First Men'.