I've used the free anti-virus ClamAV recently and this is my point of comparison. I've only ever found one (harmless) virus on a mac and that was around 1995, using norton antivirus (before it caused kernel crashes).
First impressions were not promising, net update thought I wasn't licensed, but changed it's mind on retry. You'll need to renew subscriptions each year to keep the applications working, which is around £30, then updates to the next version will probably cost £50. So this gets expensive fast.
Why so much useless packaging? This could easily come in a CD case. It could do with a printed manual or at least a quick start guide.
The virus part found no viruses, it's questionable if there are any 'common' mac viruses out there at the moment, so it's hard to judge how good it's definitions are. ClamAV found no viruses either, but correctly discovered a phishing email. Intego didn't find this, but correctly discovered corrupted files. The GUI is awful and unnecessarily flash, it shouldn't complicate matters, then doesn't automatically display results on finishing a scan. One thing it beats ClamAV on, is the speed. Running ClamAV takes forever and slows the whole system down with spinning beachballs of death. Intego virus happily works in the background, although its automatic scans of external drives can slow things down and the beachballs return. Still, I think the free ClamAV will suit most peoples needs.
Anti-spam was pointless, I'd already trained Apple Mail to effectively deal with "Junk", so having to train yet another Spam filter was annoying, but it did appear to correctly judge newsletters as spam-like, although did miss the occasional email. It maybe more useful for people that receive lots of spam (I never get the erectile dysfunction or scam emails, I'm luckily off the radar at the moment).
Updates seem very regular and often.
Netbarrier never rooted out dodgy connections, It probably correctly thinks itunes genius is spyware, which was just annoying, but things can be adjusted with some patience.
Netbarrier does a poor job explaining what it's doing, you need to understand networking to get the most out of it, it requires some fiddling. You can download the 175 page manual if you want...
I found Apples firewall worked well enough for my needs.
For me it main minus point was not having a decent printed manual which would explain the functions and trojans/viruses. It's not a great user experience for an average user. I used a copy of anti-virus to see if my mum could understand it, and it proved woeful. I'm glad I didn't try the Anti-spam version, as it would have frustrated her. It requires an intermediate user, someone with a little experience of how applications work. A photoshop user will find it easy to configure, but an ilife user may struggle with some of it. A barrier is only as good as the person who installs it, it needs to be more intuitive. People will tend to set the Netbarrier to the simplest settings and get reduced protection.
It probably does what it claims on the box, but I've yet to find a reason for having it, and at £50-£75 it doesn't seem worth it. It's interface came across as clunky and unhelpful.
As Apple Macs become more popular, perhaps it will prove useful eventually. I'd recommend you save your money for now and give this a miss.