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Infectious Behavior: Brain-Immune Connections in Autism, Schizophrenia, and Depression [Paperback]

Paul H. Patterson
4.0 out of 5 stars  See all reviews (1 customer review)
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Book Description

1 Nov 2013
In Infectious Behavior, neurobiologist Paul Patterson examines the involvement of the immune system in autism, schizophrenia, and major depressive disorder. Although genetic approaches to these diseases have garnered the lion's share of publicity and funding, scientists are uncovering evidence of the important avenues of communication between the brain and the immune system and their involvement in mental illness. Patterson focuses on this brain-immune crosstalk, exploring the possibility that it may help us understand the causes of these common, but still mysterious, diseases. The heart of this engaging book, accessible to nonscientists, concerns the involvement of the immune systems of the pregnant woman and her fetus, and a consideration of maternal infection as a risk factor for schizophrenia and autism. Patterson reports on research that may shed light on today's autism epidemic. He also outlines the risks and benefits of both maternal and postnatal vaccinations. In the course of his discussion, Patterson offers a short history of immune manipulation in treating mental illness (recounting some frightening but fascinating early experiments) and explains how the immune system influences behavior and how the brain regulates the immune system, looking in particular at stress and depression. He examines the prenatal origins of adult disease and evidence for immune involvement in autism, schizophrenia, and depression. Finally, he describes the promise shown by recent animal experiments that have led to early clinical trials of postnatal and adult treatments for patients with autism and related disorders.

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Product details

  • Paperback: 176 pages
  • Publisher: MIT Press; 1 edition (1 Nov 2013)
  • Language: English
  • ISBN-10: 0262525348
  • ISBN-13: 978-0262525343
  • Product Dimensions: 15.2 x 1 x 22.9 cm
  • Average Customer Review: 4.0 out of 5 stars  See all reviews (1 customer review)
  • Amazon Bestsellers Rank: 570,092 in Books (See Top 100 in Books)

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A chapter is devoted to an evidence-based review of the theory of a connection between vaccinations and autism. For this chapter alone, this book is worth a recommendation. This well-written book is good for anyone interested in behavior, disease, maternal-child health, and public health. Library Journal His title is a little daunting, but neurobiologist Patterson has succeeded in his aim of crafting an accessible, even fascinating, book about one of the hottest topics in mental health. In the long-running nature versus nurture argument, our era is all about nature. There is no one left -- no one with scientific credentials, at least -- who believes the way we nurture our offspring (cold mothers, distant fathers) creates autistic or schizophrenic children. But nature for too many people, experts and laypersons alike, means our genes alone. And they, Patterson shows, are not the whole story. He notes how the final health effects from the great flu pandemic of 1918, which killed more people than the Great War, played out very recently. Those who were in their mothers' wombs during the pandemic went on to a lifetime of health and socio-economic problems disproportionately worse than those of children born before or after: lower educational achievement and lower incomes, higher rates of diabetes and heart disease. Those outcomes are suggestive of the virus's effect on fetal brain development; the fact they often did not appear before adulthood supports the emerging hypothesis of the fetal origins of many adult diseases. Patterson describes the womb as a 'battlefield,' in which a fetus has to struggle to fend off rejection by the mother's immune system. Infection, which ramps up the immune response, can have devastating effects on fetal brains. The latest studies indicate that the risk of schizophrenia among the male offspring of women who come down with the flu during the first half of their pregnancies is three to seven times higher than usual. Patterson notes that common-sense ways to cut down on flu infection are widely known -- wash your hands and avoid airplane flights if at all possible -- but often ignored, even by pregnant women, because the stakes seem so small. He's done his best to correct that assumption. Macleans Neurobiologist Paul Patterson, PhD, has produced a remarkably accessible and enjoyable book that intertwines history, case studies and laboratory science... It's an engaging and thought-provoking read for nonscientists and scientists alike. Autism Speaks blog For the non-expert, this field can be more intimidating than a box of jumbled Christmas decorations. In Infectious Behavior: Brain-Immune Connections in Autism, Schizophrenia, and Depression, biologist Paul Patterson nimbly untangles the strings of lights. -- Virginia Hughes, Simons Foundation Autism Research Initiative The book is simultaneously accessible to the lay reader and insightful to the reader with more expertise. It flows like a professor who rolls up his sleeves and delivers an engaging talk to his audience without once looking at his slides. [It] is a well written, enjoyable read for any audience. Brain, Behavior, and Immunity Patterson's book is so clear and compelling that it will appeal to clinicians awaiting novel disease models with new opportunities for prevention and cure, family members endlessly pondering the source of their loved one's ailment, and any reader who enjoys medical detective stories. A lucid synthesis of historical and current thinking about 'infectious' routes to mental illness. American Journal of Psychiatry

About the Author

Paul H. Patterson, a developmental neurobiologist, is Anne P. and Benjamin R. Biaggini Professor of Biological Sciences at the California Institute of Technology and a Research Professor of Neurological Surgery at the University of Southern California's Keck School of Medicine. He is the coauthor (with Alan Brown) of The Origins of Schizophrenia.

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Most Helpful Customer Reviews
4.0 out of 5 stars Opens a new line of thinking. 3 Jun 2013
Format:Hardcover|Verified Purchase
I found it enlightening to review mental illness in terms of how biological systems and the autoimmune condition of the individual impact upon them. Of particular interest was the health of the Mother during the first trimester of pregnancy and how influenza in the Mother during this period can increase the incidence of the named conditions in the child and the outcome of Schizophrenia in later teenage years. Toxoplasmosis is also implicated as a precursor to such illnesses. It is not clear whether childhood infection with Toxoplasmosis-gondii in young life during or after birth can increase the onset of Schizophrenia in late teenage years. What I think is missing is how we can relate immune conditions to the negative aspects of Schizophrenia. For example in obsessions that relate to specific recurrent themes such as in Paranoia, where individuals can fear someone is watching them. Can we explain these more abstract features by biological precondition? Are these aspects more likely to be explained by common elements in the environment such as poverty or parenting before condition by unwell individuals?
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Most Helpful Customer Reviews on (beta) 4.8 out of 5 stars  10 reviews
8 of 8 people found the following review helpful
5.0 out of 5 stars Fascinating Research 26 Nov 2011
By Gayle Farrow - Published on
As the mother of a son who has been diagnosed with autism and a daughter who suffers from depression and bipolar disorder, I found this book fascinating. Dr. Paul Patterson presents the latest scientific research on the causes of these disorders in a way that I can understand. One part of the research that really stood out for me was that women who catch the flu while pregnant have an increased risk of giving birth to children with autism and schizophrenia, as I had the flu during both of my pregnancies. I hope that mothers-to-be will read this book and take Dr. Patterson's advice about wearing a mask in public places to minimize the risk of catching respiratory infections.
While my children have benefitted from behavioral therapy and medication, I was encouraged to read that there are many new medical treatments being studied that can reverse structural abnormalities in the brain and may prevent symptoms from ever even developing. I particularly enjoyed the final chapter, Reasons for Optimism, in which Dr. Patterson describes some of the most promising research in the field of developmental neurobiology. To quote Dr. Patterson, "There is hope!"
8 of 8 people found the following review helpful
5.0 out of 5 stars Compelling, Concise, and Puts It All Together 8 Nov 2011
By Beth Maloney - Published on
Format:Hardcover|Verified Purchase
Have a highlighter handy as you read this book because it is packed full of must-have information. The compelling, concise reporting of study after study demonstrating the link between mental health and the immune system is an eye opener. While some of the text may be a bit beyond those of us who are not doctors or researchers, the vast majority of the book is so understandable and engrossing that it is hard to put down. As a reference tool, it's invaluable. Solidly backed by research, this book offers a captivating & thorough look at how brain development and functioning is directly related to the health of the immune system. I have relentlessly advocated for the fact that an infection can cause mental illness because I am the author of Saving Sammy: A Mother's Fight to Cure Her Son's OCD. Infectious Behavior makes it easier for me to continue to insist that when the body mounts an immune response to a strep infection, the result can be a behavioral disorder commonly known as PANDAS. This book puts it all together in one place, and I highly recommend it. Beth Alison Maloney Saving Sammy: A Mother's Fight to Cure Her Son's OCD
2 of 2 people found the following review helpful
5.0 out of 5 stars Ground Breaking Research 17 Jun 2012
By John - Published on
Format:Hardcover|Verified Purchase
Patterson presents a completely new paradigm in autism research and its importance has again and again been reinforced by a plethora of research that has been published since the book was published. The recognition that autism has at it's heart the immune system will challenge many preconceived ideas surrounding genetics.

The book is easily accessible to most people with a science background although it may be heavier going for those without. Patterson's writing style makes it easily digestible within a day and then I would suggest a further reflective look at each of the chapters that are presented.
2 of 2 people found the following review helpful
5.0 out of 5 stars Best book in its category 14 Mar 2012
By Ralph Adolphs - Published on
Format:Hardcover|Verified Purchase
Neurobiologist Paul Patterson has written a fascinating book that should appeal equally to the educated lay person and the expert. As a neurobiologist working on autism myself, I found the book at once very scholarly and extremely good reading. It is full of interesting stories, deftly juxtaposes historical descriptions with cutting-edge findings, and provides a very clear account of how immune and nervous systems interact. It is in my view the best book in its category, and one of the very best in general in communicating new biological findings to a broad audience. Bravo!
1 of 1 people found the following review helpful
3.0 out of 5 stars Not for a lay audience 16 Mar 2013
By Bill Jones - Published on
Format:Kindle Edition
The science is indeed fascinating but this book is written like a science article that's had some of the jargon explained. A ghost writer or a better editor and more human data would do this book worlds of good. Looking forward to the sequel...
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