I ran Hunter: The Vigil for my local gaming group as a 'gateway' game. Few of them had played a World of Darkness game before, and rather than explain the often complex social hierarchies and detailed history of one of the other supernatural core books, such as Werewolf, Changeling or Vampire to them, I opted for Hunter: The Vigil.
During character creation, one of the players, whilst reading the description of the Long Night Compact, exclaimed "Actually, this is really well written!" I'm used to players not knowing what they want to play when creating a character for a new game, but not usually because they're spoilt for choice. Normally there's one or maybe two character options that make a player sit up and pay attention. I found that my group wanted to play everything, which is great.
The game itself does a good job of re-presenting the World of Darkness setting from the perspective of hunters, and introduces two 'new' antagonist types into the game world - Slashers - the classic horror movie tropes, and Demons - which are hardly 'new', but had not been given specific treatment in the 'new' WoD. I personally think they did an excellent job with the Slashers. See the separate World of Darkness: Slashers book published to support them.
The game offers three modes, or 'tiers', of play; normal Joe's fighting back against the dark, members of larger hunter organisations, or Compacts, or members of ancient sects or massive organisations that grant their members access to powers that blur the lines between human and monster.
This almost makes Hunter: The Vigil three games in one, as each tier differs greatly.