I've just bought the Blu-Ray series of this having watched the series on TV.
This series explores a different side to the inimitable Dr House. I'm sure you are already familiar with him if you're looking at Season 6, so I'll be brief and only say that we now see him attempting to confront his drug addiction and its aftermath.
As an ambiance, this gives season 6 a lot more depth in character development than previously, and something which may feel odd is that the medical cases actually take a back-seat in some of the episodes which has rarely happened up until now. Having said that, I did not find this jarring as I've been totally sucked into the love-hate relationship most viewers have with House. He's still rude and obnoxious to most people but his relationship with Wilson gives him an element of humanity we just can't let go of - in this vein, season 6 is a lighter and brighter affair than the crushingly dark (but still brilliant) Season 5, more akin to the earlier series. Something many fans will love is that the original team are reunited for a big part of this series playing far more pivotal roles than in the last few seasons, and the private detective Lucas returns as a semi-regular character - in a very surprising way!
From the opening episodes, 'Broken', to the suspense packed finale, 'Help Me', I was hooked and couldn't wait to watch the next. New characters like the manic Alvie, and level-headed Dr. Nolan crop up too, and worm their way silently into your heart in unusual ways - something only House is this good at as in any other show, the balance wouldn't work and they'd just be irritating distractions. This series is a must.
You get a lot of extras on the Blu-Rays which were great, including a behind the scenes with Hugh Laurie which was especially interesting and commentaries on important episodes.
If you own an iPhone or smart phone, there is also a great feature called 'pocket BLU'. This enables you to use your wifi phone as a remote for internet connected Blu-Ray players, and you can scan episodes and scenes on your device, rather than through the player menus which are far less visual or intuitive. This little add-on is fantastic and was worth the extra few pounds on its own in my opinion. Why all Blu-Rays aren't using this beats me as it's very useful indeed.
In addition to this, you get the usual deleted scenes, trailers and other bumpf, but for me, pocket BLU and the HD quality made this a very worth while purchase.