'House of M' takes off from the 'Avengers: Disassembled' series, so I'd recommend giving that a read beforehand or at least glancing over a summary. If you're looking for a lot of action then you might be slightly disappointed with this, as whilst it does have its fair share of fighting, it primarily focuses on how much the world has been messed up and how our heroes deal with that and are emotionally affected by it.
It's more suited towards the more experienced comic fan, as there are quite a few less-than-famous Marvel characters involved who I wasn't familiar with. The collection is drawn by the brilliant Olivier Coipel and as a result the art is fantastic. I'd certainly recommend this to anyone in the mood for a well-drawn, well-written major event set in the Marvel universe.