I can't understand why Thomas Wolfe isn't as widely reprinted as Hemingway or Faulkner, because his work is up there with them. Like Richard Yates and Revolutionary Road, it might take Hollywood making a film of this book to make it really popular again, which would be a sad reflection on a book like this.
Look Homeward, Angel is semi-autobiographical, but this does not make it sentimental. It is steeped in nostalgia, and anyone who naturally reflects on the past and sees the melancholy in irretrievably lost time, missed relationships, and things left forever unsaid, will understand where Wolfe is coming from. The story is of a Southern family called Gant; it follows one son Eugene's growth from birth to adulthood, and is written with both a wisful sadness and an irrepressible joy for living. The writing is superb, in some places the best prose I've seen. The dialogue, especially from members of the Gant family, is both touching and hilarious, and because of this all of the characters are vivid and detailed, without fail.
The book is fairly long and intricate, but this should not put you off, think of Dickens and the detail that makes his work so great too. This is not a quick read type of novel, which is probably why it only got one star from the book club reviewer (wholly undeserved - don't blame Thomas Wolfe for not being Dan Brown). In my opinion, Look Homeward, Angel has far more to offer than almost any other American novel I've read.