Though this book has its problems, it is an excellent guide to winning holdem stratgy. Apart from the fact that most decent holdem players would have at least read it and so will (in tougher games) employ most, if not all, of the stratgies discussed, it uses an easy to understand format to discuss some complex plays and how to adapt them to any situation.
The problems however are that a lot of the ideas are applicable to tight aggressive high limit games, which the authors now frequent. With the explosion of poker, especially the online varient, you will find a large quantity of weak loose passive/aggressive players playing on the lower limits, where many of the plays described in the book will be wasted. Though there is a section on how to play loose games, if this is your game of choice, you might be better off buying a book devoted to the subject.
Also pot limit/no limit is mostly played in Britain and this book is meant to be applied to the limit games prevalent in America. However there are no books which focus solely on this available and the concepts are still valid.
The last problem is that it might encourage you to play too rigidly to their guidelines, ie the constant use of the hand tables. Winning poker play is about how to use your cards in the best possible way in a particular situation, rather than following a set of rules.
All in all though, this is a must buy for any serious player. Many people consider this to be the 'bible' of Texas Hold'em, and after you apply these stratgies to your game, you will probably agree with them.
(As a direct response to gamboler, the chance of making your flush from any two suited cards is about 13%, and anyone can see that if you have two suited cards, you are more likely to make a flush than if you have one. The reason why Sklansky rates J 10s as high as A Q is because it is a large money maker in multiway pots, compared to A Q, which will probably only win a small amount of money heads up)