I cannot give enough praise to Ennis and McCrea's Hitman series; I thought Preacher was Ennis' masterpiece, but Hitman is special in its own way. Not necessarily as profound and philosophical as Preacher, but perhaps a tighter weaved story that perfectly captures the essence of nobility and friendship, and resonates more in more my heart, whereas Preacher tended to challenge my mind. It is amazing that it took so long to collect this fantastic series in its entirety and that it has existed for so long, unknown by so many.
First, if you have not at least read Volume 1, this will not be a good starting point. To me this is where the series really began to come together, and Ennis begins his masterful job of weaving together all of the story threads of the series thus far while setting up the events towards Closing Time. Building off of the events of Volume 1, the Lords of the Gun send the Mawzir back to confront Tommy and gain his revenge for what transpired in the first volume. Bringing together Catwoman, Jason Blood, Baytor, Section 8 (who cannot forget Dogwelder, no matter how hard you might try), and Noonan's gang, Tommy must defend against the combined forces of Hell and the mob while taking residence in a church. This story mixes together surreal elements, dark humor that could only come from the demented mind of Ennis, but also a tale of burgeoning love, and what it means to stand up for your friends. The subsequent story (the only issue not drawn by McCrea) is one of the sweetest, funniest, bloodiest issues and ultimately the catalyst for a series of events that lead to the series finale. When looking back it is amazing how Ennis set up events in the first 20 issues of the series that took 40 more issues to ultimately reach their resolution.
Ultimately, I hope you give each volume of this series a read, I do not know that I have read a series with more genuine heart and such an endearing cast, while also providing surreal and dark comedic moments. This is a truly unique series from DC that found a very interesting niche on the fringe of the superhero genre.