I've just set this up on our main desktop PC via the cable and to my laptop via wireless and I have to say it's the easiest set up I've done!!
I read lots of reviews on different sites about this printer/scanner/copier before I committed to buying it and generally the only negative comment was about setting up the wireless but I found it really easy, I just followed the instructions that the disk gave me and it went smooth as anything.
We only need this for family use so nothing hard core but still college work and work documents and photos for the family. I've tried it already on a couple things via my wireless connection and it runs exactly the same as any other printer, not too loud, very very fast and the finished product was really good.
I'm glad I got this and I wanted to let everyone know that a young mum who really isn't any good at technical stuff managed to set it up by herself after being awake 20 hours ... if that isn't a simple system of setting up then I don't know what is!