In modern day Italy, Gunslinger Girl, looks into the antics of the Social Welfare Agency. Their mission is to rehabilitate human lives but secretly they act as a counter terrorism and counter intelligence unit. The SWA chooses a girl in a near death condition and through a series of experiments, where her body is fitted with cybernetic parts and her memories removed, create the perfect government-commissioned assassin. These new parts and a compliance inducing drug heighten her perceptions and allow her to anticipate danger, but extensive use strains the girls mental and physical endurance shortening the girl's long-term memory, as well as her life span.
A male agent is assigned to the girl as a handler. The 'Fratello' trains, conditions and develops the girl. Each girl is treated individually but the end result is a deadly assassin with undying loyalty to their handler. The Gunslinger story focuses mainly on the relationships between the girls and the handlers, the parody between child and assassin makes for interesting personal and emotional conflicts. Fans of the series describe it as a controversial and emotionally depressing story that takes a deep look at human nature, and even though the girls have no past memories, the girls still have a soul and humanity.
The manga published in English is currently composed of ?three?(17/06/06) volumes although it is unknown whether or not they will continue to translate the series. The corresponding amine is currently doing very well and I would recommend starting there. But, these volumes would, if the future of the series was secure, make for an interesting read.