The Greatest Experiment is a fascinating book. It offers a valuable history of estrogen use from World War II to the present. Barbara Seaman, a well known science writer, has been following the estrogen story for years and was able to interview many of the major figures in the field. The story of how menopause came to be viewed as disease, how a dangerous drug was prescribed to women as a tonic for brittle bones, heart disease and Alzheimer's disease on the basis of circumstantial evidence is, indeed, compelling. The struggle to expose the side-effects of estrogen-derived birth control pills is also told. This led to Congressional hearings and forced drug companies to provide information on the side effects and dangers of birth control pills. The Greatest Experiment contains much more including the tragic story of the DES daughters (whose mothers received diethylstilbestrol, an estrogen derivative, to prevent miscarriages and gave birth to daughters who experienced life-long reproductive problems.) Also told is the troubling use of DES by farmers who still use it to fatten livestock. Finally, the book has an excellent Appendix on the options now available to women who seek treatment for symptoms of menopause.