Genesis of the Hunter, author Joshua Martyr's debut novel, presents the story of a single vampire's life during two time periods: his initial transformation in the 1400s, and his quest during modern times to fully understand the genesis of his species.
The passages that take place in Berwick Upon the Tweed during the late 1400's detail the chance encounter with two vampires that forever changes the life of The Sentry, as we know the vampire during this time period. In fascinating detail The Sentry's process of transformation into a vampire is chronicled, including the fact that for some reason he retains a higher level of intellectual functioning than the creatures whom he fought did.
Flash forward to modern times where Gabriel, as we now know The Sentry, has employed immunologist / hematologist Dr. Canterberry to study the evolution of the vampire species. The investigations are being carried out both with urgency and in the utmost secrecy as there are people in shadowy positions of power (the CIA, Knights Templar and Illuminati are all hinted at) who seek to capture Gabriel in furtherance of their own agenda.
Author Joshua Martyr certainly has a grand vision of the story he wants to tell regarding the evolution of the creature we call vampires. As Richard Matheson's 1954 I Am Legend did, Genesis of the Hunter contains a substantial exposition on the possible scientific explanations for the existence of the vampire, and Martyr has put considerable effort into creating a scientific backstory on the evolution of the species.
The two time periods that alternate in the story could well have stood on their own as separate books, and the only minor quibble I had is that the jumping back and forth in time was a bit distracting at times. Having said that, there is no question that Martyr's approach is from a refreshing perspective, one that is not centered on either romance or gore but takes a more analytical approach to the legend.
So if you're looking for a story that tackles the legend of vampires with a blend of historical setting and scientific theory, give Genesis of the Hunter a try.