I was a research fellow in CalTech's Kerckhoff Laboratories of Biology when Jim Watson arrived in the autumn of 1953 to join us as a research fellow. Everyone was curious about the person who had come from nowhere to make, along with Francis Crick, one of the great discoveries of the twentieth century. I found him to be very bright, friendly, and bubbling with ideas. Genes, Girls, and Gamow describes the ferment in biology at that time, and his attempts to apply intuition to the problem of how information in DNA translates into proteins. But much of the book is a candid account of his search for the perfect girl to marry. We go through his attempts to woo a string of CalTech girls - all failures. I once suggested to a pretty, intelligent lab assistant that he would be a good catch, since he was sure to get a Nobel prize. She gave me a look that would have frozen melted steel, so I kept silent after that. The account of his pursuit of undergraduate student Christa Mayr is almost painful to read, since he loves her, but she is only lukewarm. It all comes out well, however, when he finally finds the girl of his deams. The third part of the book's title, the physicist George Gamow, flits in and out of the story in the same way that he would appear at CalTech and then disappear. The book reminds me a bit of The Diary of Samuel Pepys, since we read where Watson went, with whom, and what they discussed. If you would like to read an insider story of the way that much of our current biology developed explosively in the 1950's, this story gives you a month by month diary. Jim Watson's candor makes it fascinating reading.