Some time ago, Bones Studio created an anime called "Fullmetal Alchemist", based to a point on the manga by Hiromu Arakawa. However, the manga hadn't even reached its halfway point in the storyline yet, so Ms Arakawa generously conceded that the director of that anime could take the storyline wherever he and his creative team wanted to go with it.
This created a dual universe for Fullmetal fans... the one of the anime, and the one of the manga. There are probably more people familiar with the first anime just because it's very, very easy to get caught up in the world it creates. Also, it's always been simpler to watch a video than read, even in a medium that's loaded with visual imagery.
Until 2009, when a new anime of the story appeared, called "Fullmetal Alchemist: Brotherhood" to clarify one from another. The new anime is very, very close to the storyline of the manga, although sometimes that's not "all that different". The Japanese voice cast has largely changed since the first anime's time, excepting the well-known Romi Park/Paku and Rie Kugimiya, who play Edward and Alphonse Elric respectively. On the English voice cast, it's largely unchanged, although noticeably puberty has robbed Aaron Dismuke of the Alphonse duties, giving the opportunity to Maxey Whitehead. "Brotherhood" starts with an adventure that tries to introduce everybody to the new series, even adding a new character that has been in neither the first anime nor the manga, but had been designed by Hiromu Arakawa herself. The first story gives a good feel for the new artistic style (similar to that from the first anime, but softer, yet including more manga-esque gags like chibi-heads) while also introducing the major characters smoothly for those with no familiarity with the Fullmetal universe.
The extras are not plentiful... disc one has a commentary "for Episode One" with ADR director and voice of Second Lieut Havoc, Mike McFarland, voice of both Riza Hawkeye and Rose, Colleen Clinkenbeard, voice of Col Roy Mustang, Travis Willingham, and the new voice of Alphonse Elric, Maxey Whitehead. They don't talk about the episode; they talk about their characters and how each character has changed between the first anime and "Brotherhood", and about how their families can watch entire episodes of anime they have done voices for without those family members recognizing the beloved relative. It's interesting as a look into the business of voice acting, but hardly more than that. The second disc has a similar commentary for Episode Ten, with Sonny Strait, voice of Maes Hughes, Laura Bailey, voice of Lust, and Caitlin Glass, ADR Director and voice of Winry Rockbell (they get very, very giggly during their chat session). It also includes textless playbacks of the opening and ending sequences of "credits" animation with the amazing music playing throughout.
If you liked the first anime, you'll probably enjoy this series. If you like the manga, you will NEED to buy this set as soon as each volume is released. And if you've never given anime a try, thinking it was for weird geeky people... just watch "Brotherhood". Welcome to the Dark Side... we have cookies!