DFW (as he would no doubt abbreviate himself) tells an interesting story of the struggle with transfinite numbers from ancient Greece to the 20th century. Although intended for a general audience, I think that, without quite a lot of maths behind you, this book would be pretty hard going. As someone who was familiar with most of the concepts, I found the presentation often seemed willfully obtuse (especially when he claimed to be making it extra-simple).
The book is peppered with the usual Wallace-isms of abbreivations, footnote, interludes and interpolations. The abbreviations were often unhelpful; the footnotes often very interesting. In some places his style makes the book very entertaining and in others infuriating.
Ultimately, I found this book an enjoyable read but mostly from the historical perspective. The technical content is variable and the really interesting stuff at the end is (perhaps necessarily) only given a very cursory discussion. I wouldn't recommend it for the layman, and it might annoy the expert, but I think there is fun to be had for those with a bit of background in the subject and a mind open to a pretty unique mode of presentation.