Rebuild of Evangelion 2.22 is the second of four 're-imaginings' of the Neon Genesis Evangelion universe. It is a direct sequel to 1.11 You are (Not) Alone and should definitely not be watched without having seen 1.11 or at least 1.0 before.
Unlike 1.11, 2.22 takes a huge divergence from the original story of Neon Genesis Evangelion- whereas 1.11 was a retelling of episodes 1-6 with some slightly changed scenes, 2.22 features a new character and new Angels, with a much greater focus on entirely new content, with very little of the film being the same as in the original series.
2.22 is much like 1.11, however, in that it is incredibly well-animated and gorgeous to look at, with excellent voice tracks in both English and Japanese. The film's soundtrack is also incredible, with recognizable themes from the original TV series being brought up to modern standard, and with entirely new songs as well.
Ultimately, Rebuild of Evangelion 2.22 is an incredible film by all standards, perfect for both fans of the original series and for anybody with an interest in Anime.