I was blown away by this film. It tells a fairly basic story; young girl, bullied at school, belongs to a dysfunctional family, with aspirations of being a surgeon, who is also undergoing a sexual awakening.
But this is no ordinary lo-fi teenage drama, for two reasons; firstly, the girl in particular, Pauline (a superb AnnaLynne McCord) is having very surreal, sexual dreams involving vomiting, autopsies, and lots of naked people, and secondly, because the denouement of this film (which I couldn't possibly ruin) elevates it into something darker, and makes it a masterpiece. The final shot is one I will never forget.
Added to this, Traci Lords is phenomenal as Pauline's mother, perfectly playing a woman who is torn between a maternal duty to her daughter and the fact that, at the end of the day, her daughter is a truly unpleasant girl who does not make it easy for anyone in her family.
John Waters and Malcolm McDowell also make excellent cameos, in roles that actually serve the plot as opposed to just being a tactic for drawing in more people.
Overall, this is an excellent film that no doubt will develop a very devoted and large audience as the years go on. You can count me in already. This is probably the best example of the "everything is out of kilter" I've ever seen, and it certainly stands comparison with films like Carrie or Gus Van Sant's Elephant. One of the best films of last year.