In the dizzying world of New York fashion, where size zero is the new 2, six is the new 8, and a bad hair day can end a career, Runway Magazine is the Holy Grail. Overseen with a finely manicured fist by Miranda Priestly (Meryl Streep) - the most powerful woman in fashion - A stint as Miranda's assistant could blast-open the doors for recent college graduate Andy Sachs (Anne Hathaway).
To become the perfect assistant, Andy will need to make herself over in Miranda's image. Soon, much to her boyfriend's (Adrian Grenier) dismay, she can talk the talk, walk the walk (in flawless Manolo's) and never again confuse Dolce with Gabbana. But the more of life she sees through Miranda's eyes, the more she begins to grasp that Miranda's world is a fabulous but lonely one - and that sometimes great success depends on great sacrifice...but at what cost?