Cthulhutech is a game that made a lot of people do a double-take when it was first announced. The bleak, sanity-blasting horror of the Cthulhu Mythos mixed with anime influences such as Neon Genesis Evangelion, Guyver, and Macross? It sounded bizarre and to many unfamiliar with the game, it still does.
But I'm here to say that the game absolutely takes the seemingly incompatible parts and makes an incredible whole. The setting takes place in the future when the Earth is under attack on all sides from foul cults, arrogant and disturbing aliens, and incomprehensible monsters. Things look grim, but humanity is still managing to hang on and survive.
There are a lot of different playstyles, anything from street level investigations (similar to classic Call of Cthulhu) to giant mecha military campaigns to government special forces to secret society operatives bonded with extra dimensional beings to fight evil. The mechanics are new, but not terribly difficult to understand. Further, the art for the game is gorgeous and really draws you in to the setting.