I used this some time ago and run out and didn't think about buying anomyore as wasn't having any issues. But since taking them again I can feel the differnce in my lower back where I have a prolapsed disc. It can sometimes be quite painfull but when taking these it definately helps. I don't take them everyday as they are quite expsive, every other day along with normal Glucosamine Tablets. As i'm an active sporty person (Football, Cricket, Gym) I feel it beneficial to take them to keep me running smotthly. Plus i'm really prone to injury due to a bilateral sports hernia opertation and my prolapsed disc in my back.