This a disappointing guide book, perhaps the least useful I have ever bought and far short of the Lonely Planet's usual excellent standards.
There are four problems.
First, the book is structured as a series of themed trips. There is nothing wrong with this per se but you are quite likely to find youself in place that features in 3 or 4 trips and the cross-referencing between trips is poor.
Secondly, the book lacks much of the information that makes guide books useful. This is true on many levels; for example: there is none of the historical and cultural information usually found in Lonely Planet guidebooks that puts the places being visited into context; there is very little of the basic factual information (such as museum opening times) that you expect to find in a guide book; and there is very little information on places to stay (with the few places picked out generally being high end).
Thirdly, the book is heavily biased towards food; many trips are centred entirely on food and places to eat feature extensively in other trips. This will appeal to foodies but not to travellers with broader interests.
Finally, the tone of the book is odd and irritating - it is a weird blend of right-on folksiness and 1950s travelogue; so you will find youself being told to "bid adieu to sweet Hwy 17", to "head back downtown and have a spiritual experience", and to "let some chopped pork slap you on your taste buds...".
The Lonely Planet guide to "Louisiana and The Deep South" (currently out of print) is much more useful