I've always struggled to find a sports bra that is comfortable (lightweight and wicking) and supportive. This bra is both, and I'm a fan. It rinses out well in the sink, and I only put it in the washer about once a week. It has held up great with that care.
I really dislike sports bras with any sort of metal or plastic closure device (snaps, zips, hooks, etc) because I've found they cause chafing, and bruising if I'm doing situps and such. However, most of the sports bras for larger chests tend to include these elements. The CW-X Firm Support Bra doesn't, and it keeps my girls from aching after a long run. It's almost magic!
It is difficult to get this bra on and off, but with practice it becomes much easier. It gets easier if you're less sweaty, so it's good incentive to ensure you cool down properly after your run and stretch. If you don't want to deal with hooks or zippers, there isn't much alternative because if it stretched to take off easily, it would stretch when you didn't want it to also (while running).