Each of the 4 disks presented different problems when installing in Vista. Settings needed to be changed in different ways each time, one needed a download patch to even get it working in English and, even after all that, the first disk won't play right to the end despite everything.
OK, Vista is a pain in general, so maybe this isn't all the game's fault - and CSI games are pretty good to play as a rule; but unless you are reasonably adapt at configuring your PC (or you have some reliable assistance to hand from a tekky friend), I'd advise you think twice before getting this for a Vista PC or laptop.