I've read mixed reviews about the Vapor Dry 2 with most comments centering on whether or not it is sufficiently warm for various cold weather runs. Up front, it is not a cold weather glove, and it isn't designed to keep the wind blowing through the shell, but I also haven't seen it marketed as a cold or extreme weather running glove and do not expect to perform as one. Expectations that this glove will keep your hands warm and toasty with temps below 20 degrees are probably unreasonable.
The bottom line is that it depends on the individual runner and his/her tendencies during running. Some runners' hands warm up after a while, while others do not. If you have hands that don't get warm during runs, then this is probably only good as a cool weather glove for you, but insufficient for colder temps in the 30s or colder. If you tend to have hands that warm up during running in cold weather, these will be good enough for most runs down to around freezing temps (low 30s F / 0 C). From my own experience, I've worn these lately on 6-8 mile runs in as low as 26-degree weather, and my hands were cold for the first mile but warm afterward, but I am a warm-hand runner.
As for wind-blocking capability, don't expect much. The material is a mild insulator and doesn't block the wind very well as it is designed to be breathable. This design feature, however, gives it greater range in warmer weather. I like to wear gloves even in warmer weather to wipe away sweat from my brow and grip water bottles with sweaty hands without fumbling. It is light and breathable enough to keep your hands from overheating and wicks away sweat during warmer weather and serves as a non-slip bottle gripper and sweat wiper. The grippy material ringing around some of the fingers and on the finger tips are good for reducing risk of inadvertent container fumbling regardless of temperature.
The terry cloth on the forefinger and thumb as well as lower palm is softer than on most other similar gloves I've tried and thus less abrasive on your skin after accumulating some dried sweat. I do not use any iPods or MP3 players while running, so I cannot attest to the thumb pads' ability to utilize these devices, but it worked sufficiently on my Garmin touch bezel.
I do wish that these gloves had a hidden pocket on the back side of the hands like a pair of Nike gloves I have that allow me to port an ID card or even gel packs that your hands keep warm.
Overall, this is a good enough glove for most of my runs that require gloves.