I've been interested in BLAME! ever since I found an art book on an import website. After readint through the volumes in Japanese, I must say I wasn't let down. This series is easily one of my favorites. Unfortunately, It also takes a while to get going.
The ten volume series tells the story of Killy as he wanders through the what was once the earth, and now is a gigantic city known as the megastructure which grows out of control. Despite it being a city, few humans are to be seen due to an infestation of beings known as Silicon Creatures (essentially cyborgs). Killy seeks the net terminal genes, or an individual who has them, in order to restore ballance to the city. He thus faces the perils of the megastructure armed with a superhuman constitution and a small pistol that punches holes two feet in diameter through whatever it hits.
What really sets BLAME! aside from many other manga is the unusual art style. Though it still contains the general feel of most Japanese comics the characters never seem to focus their eyes, which can be hard to get used to but adds to the lonely, hopeless atmosphere of the story. The also has a rather messy style, which may appeal to some but not to others. The factor that elevates the artwork though are the environments. From great bridges to monolithic towers the backdrops are truly masterpieces in their own right. The detail and depth is simply unmatched.
Unfortunately, the series suffers from a slow start, and thus the first volume is not up to par with the rest of the story. The artwork is still in its early stages, and visually improves as the series progresses. There are no monumental plot shifts in the story either. It's really more of an introduction. The story and artwork also appeals to only a limited audience, due to a story that requires a lot of thinking to fully understand (though perhaps not in this volume). Still, if you're looking for something unique with an art style that stands out and a story to match, BLAME! offers something that breaks away from the conventional.