I have been using these occasionally for a few years now and have noticed a difference in my pores, especially on my nose. I like how they have added slits around the nose strips to help prevent the wrinkles and bubbles on the strip I used to get. The package recommends not using them more than once every three days. I use them twice a month (or when I remember) and use the Biore triple action astingent immediately after removing the strips. I have had no adverse reactions to this item. You should not use if you have sunburn, blemishes, excessively dry skin or are sensitive to bandages or peel-off masks. Also, stick with the Biore brand, I have tried drug store knockoffs and they ARE NOT the same.