First Sentence
The hydrolysis of a minor membrane phospholipid, phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by a specific phospholipase C (PLC) is one of the earliest key events in the regulation of various cell functions by a number of extracellular signalling molecules (1). Read the first page
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acid
actin
activate
activated
activation
activity
although
appears
between
bind
binding
biol
catalytic
cells
cellular
complex
contain
different
domain
effects
enzymes
evidence
factor
family
fig
form
formation
function
gene
gpi
growth
homology
however
inhibit
inositol
interaction
involved
journal
kinase
levels
lipid
mammalian
may
mechanism
membrane
molecules
nature
p13k
pathway
ph
phosphatase
phosphate
phosphatidylinositol
phosphoinositide
phospholipase
phospholipid
phosphorylated
phosphorylation
pi
pi3ks
pitp
pkb
plasma
plc
pld
protein
receptor
region
regulation
required
residues
response
results
role
see
sequence
several
shown
signal
signalling
site
specific
structure
studies
substrate
subunits
suggest
surface
synthesis
transfer
two
type
tyrosine
vesicles
yeast
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