- Pre-order Price Guarantee: order now and if the Amazon.co.uk price decreases between the time you place your order and the release date, you'll be charged the lowest price. Here's how (terms and conditions apply)
Did you know you can trade in your old books for an Amazon.co.uk Gift Card to spend on the things you want? Visit the Amazon.co.uk Trade-In Store for more details. |
Special Offers and Product Promotions
Product details
|
Product Description
Product Description
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein–ligand crystal structures. In the final part, several real–world examples of bioisosterism in drug discovery projects are discussed.
With its detailed descriptions of databases, methods and real–life case studies, this is tailor–made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein–ligand crystal structures. In the final part, several real–world examples of bioisosterism in drug discovery projects are discussed.
With its detailed descriptions of databases, methods and real–life case studies, this is tailor–made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
About the Author
Nathan Brown is the Head of the In Silico Medicinal Chemistry Group within the Cancer Therapeutics Unit at The Institute of Cancer Research in Sutton (UK). He conducted his doctoral research with Prof. Peter Willett at the University of Sheffield, before moving to Amsterdam (The Netherlands) for a Marie Curie fellowship in collaboration with Prof. Johann Gasteiger. This was followed by a Presidential fellowship at Novartis in Basel (Switzerland). Dr. Brown has published in a wide range of areas of computational chemistry, most notably de novo design and molecular descriptors.
Tag this product(What's this?)Think of a tag as a keyword or label you consider is strongly related to this product.
Tags will help all customers organise and find favourite items. |
Sell a Digital Version of This Book in the Kindle Store
If you are a publisher or author and hold the digital rights to a book, you can sell a digital version of it in our Kindle Store.
Learn more
Listmania!
Look for similar items by category
- Books > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
- Books > Science & Nature > Chemistry
- Books > Science & Nature > Engineering & Technology > Bioengineering
- Books > Science & Nature > Engineering & Technology > Chemical > Industrial Chemistry > Pharmaceutical Technology
- Books > Science & Nature > Medicine > Medical Sciences A-Z > Pharmacology
- Books > Scientific, Technical & Medical
Look for similar items by subject
Feedback
- Would you like to update product info or give feedback on images?
- I am the Author, and I want to comment on my book.
- I am the Publisher, and I want to comment on this book.
|
