I use ZoneAlarm Internet Security Suite 6 and a free copy of Ad-Aware Se with all the latest updated spyware profiles.
I take security of my PC and home network extremely seriously, I haven't been bitten with a virus since 2001 when my hard drive got wiped (once bitten...) I run deep scans and virus checks on every pc at least once per week. Everything seemed OK.
Until I ran this application, it ran a deep sweep that took about an hour and located in total 58 variations of spyware (2 keyloggers, 2 backdoor exploits, the list went on and on) I used Spyware doctor to remove the offending files and have noticed a slight improvement in my system process time.
What can I say, I had never heard of this application until it came up in a PC Pro Review stating that if they could, they would rate it 6/5 stars.
They rate the application that highly that its' performance is used to compare against the performance of the anti spyware software that is bundled with all the current Internet Security packages. (none of them can beat it)
Conclusion: With this software and ZoneAlarm Internet Security Suite 6 I don't think I will be having any reason to worry for another long year.