Mortimer Brewster (Cary Grant) has a problem. He's a newspaper critic known for his complaints about marriage, who just got married. Before the news breaks he wants to tell his two nice, elderly aunts, but when he arrives at their home he discovers the aunts have a combination hobby and charity. They poison lonely old men, then have them buried in their basement by their addled brother who thinks he's Teddy Roosevelt. "Teddy" is concerned about all those yellow fever deaths, but digging the locks for the canal provides a logical burial place. When Mortimer discovers his aunts' 13th work of charity in a window seat, his troubles are just beginning. Showing up unexpectedly is Mortimer's criminal brother, Jonathan (Raymond Massey), an escaped psycho who, thanks to the botched facial surgery of his partner, Dr. Einstein (Peter Lorre), now resembles Boris Karloff. And wandering in and out are some great character actors, including Jack Carson as a play-writing cop, James Gleason as a police superintendent, Edward Everett Horton as the head of a home for the insane, and Grant Withers as a bemused clergyman.
What could not be funny with such a setup and with such actors? Well...Cary Grant, in my view, nearly does the movie in. Grant (or Frank Capra) seems to think playing farce means squatting and walking like a chimpanzee, talking as loudly and fast as possible, and mugging broadly for the camera at every opportunity. There are many good things in this movie, but, for me, Grant overacts, something he rarely did in his other films. I suppose the blame rests with Capra.
Hull, Adair and John Alexander who plays Teddy originated their parts in the stage presentation. One of the funny conceits was that playing Jonathan on Broadway actually was Boris Karloff. I've been told that when the movie was filmed the stage play was still doing good business. The producers let the three take six weeks to make the movie, but wouldn't release Karloff. They thought he was too important for ticket sales. It's too bad. As good as Raymond Massey is in the role (he shows a real flair for deadpan humor), having the real Karloff become enraged because his surgeon botched the operation and made him look like Karloff would have been unusually funny.