Having already done a Computing Science degree, I was a bit skeptical about what I could learn from this book, however, the answer is a lot.
I had covered things such as digital circuitry, and assembler at University, but this book bridges the gap that my little dutch lecturer failed to explain.
The book can be followed at your own pace and has frequent user experience examples. I got through the book (without companion replica1 building) in a day, and should I ever come across an Apple1 or Replica1, I would now know exactly what's going on.
All the major elements of the computer are explained, in their parts and how they integrate. Most of these elmenets are still found in modern computers (albeit faster and smaller than here).
If you want to learn how the first computers were designed and built, and even build one yourself, this is the book for you.