Resnais' penchant for film as cognitive experience first and foremost here comes to the fore, although emotion is certainly on display as well. The three main characters of the film--an actress turned fashion industry stylist (Nicole Garcia), a media executive (Roger Pierre), and a textile middle manager (Gerard Depardieu)--all undergo changes in their lives that intertwine with the theories of human behavior put forth by Professor Henri Laborit, a famed French psychologist and scientist, who plays himself in the film.
Bearing in mind that the film was made in 1980 and that psychological theory has advanced significantly since then--largely founded on one after another breakthroughs in neurobiology/neurophysiology--this is nevertheless an entertaining piece of cinema whose theme is really how we respond to external circumstances--specifically, those that could potentially be very stressful.
For some people, a specific circumstance will be manageable; for others, it will be tremendously stressful. In this film, all three main characters respond to various experiences as very stressful ones, and consequently exhibit behaviors reflecting that: attempted suicide, psychosomatic illness, emotional outbursts. Laborit comments on the reason for this stress, which is primarily the inability to dominate (i.e., control) a situation. Regardless of new discoveries in neurophysiology, his statement is absolutely true, and Resnais fuses Laborit's voiceover discussion with interrelated events in the lives of the three main characters that illustrate the scientist's words.
Once in a while, Resnais gives human characters the heads of white lab rats to wittily capture Laborit's points (not for long; just a few seconds or so). Yet in spite of this visual cleverness, the dexterity of the lead actors embodying the emotional intensity they experience given certain changes in circumstance is truly skillful.
What's also interesting is that, early on, two of the three characters profess their love of past French film stars--in particular, Jean Marais and Jean Gabin. When each of these two (the Nicole Garcia character and the Gerard Depardieu character) are confronted with these changes in circumstance, Resnais cuts to a snippet of a scene from a film starring Marais (for Garcia) or Gabin (for Depardieu) in which the viewer can easily tell the emotion experienced by the older actor. This is, again, a clever cinematic device that adds to the film's richness.
Rated one of the best films of the 1980s by numerous film critics, Mon Oncle D'Amerique is a substantial piece of work that bears a number of viewings. It's easy to see why the critics voted this way.
Highly recommended.