Mercury-containing "amalgam" fillings have been with us for 150 years, and have been the intermittent subject of vehement controversy for just as long. In the 1850s or 60s, for a while it was a crime to insert these fillings into human beings in parts of the United States. In the 1930s Alfred Stock, a brilliant chemist, wanted these fillings banned; various American dentists have urged the same since the 1970s. In Sweden they were banned until the European Union intervened. The use of mercury to treat syphilis, as was customary into the 1890s, is now a huge embarrassment; many of the "symptoms" attributed to syphilis are now known to have been due to the "treatment."
In various European countries, the medical fraternity acknowledges that mercury, being a liquid, slowly evaporates from these fillings. This is where things become complicated. Cutler adduces evidence from different journals that the ability to excrete mercury varies by more than a factor of 20 between humans; in other words, as in lactose intolerance, a minority of human beings can't tolerate an otherwise safe product. Even more counterintuitively; mercury poisoning, unlike other intoxications, does not have a single set of symptoms, but rather at least 20 very different sets of symptoms. I was initially deeply skeptical of Dr. Cutler's claims, which are at odds with everything you hear from "mainstream" medical authorities. However, the more I delved into the established scientific facts, the more confirmation I found for his claims. As part of my quest to regain my health I obtained excerpts from a 1400 page post-doctoral thesis on the side-effects of amalgam fillings by a dentist who went on to post-doctoral studies at Harvard University. Unfortunately this thesis has yet to be published, reportedly due to pressure from the (so-called) National Institutes of Health. In any event the excerpts fully support Dr. Cutler's claims.
If these fillings can cause mercury intoxications, the question arises how to treat such states. As Alfred Stock experience proved, some people can recover by simply having their fillings removed; others can't. Were I sure that I was so poisoned, I would consider waiting to see if my body can heal itself depending on the severity of the intoxication, and not immediately rush to treat it chemically, a consideration Cutler unfortunately omits in this book. For those who can't recover unaided, Dr. Cutler's book is invaluable. Many in the "alternative medicine" community "treat" mercury intoxications with chorella, an algae that forms loose bonds with mercury. This does sometimes help, but in talking with dentists who will talk frankly about amalgam issues, I have been told that Cutler is correct in writing that some people have significantly harmed themselves this way.
Cutler advocates the use of chelators with two adjacent sulfur atoms, which form bonds with mercury that are much stronger than those that chlorella forms. Toxicologists use such chelators - and not herbs - to treat mercury intoxications because they know what they are doing. Most toxicology handbooks note that none of the customary chelators used to treat mercury poisoning (DMSA or DMPS) meaningfully penetrates the blood-brain barrier; in other words, if you have a lot of mercury in your brain, and can't move it out once you've reduced your exposure, they can't help you. Cutler happily found that lipoic acid, a medication sold in Germany for the last 40 years, gets into the brain, and removes mercury from the nerve cells; some clinical work with a lipoic acid derivative in this regard was done in Poland and Russia. In other words, Cutler accomplishes what most toxicologists believe can't be done. Cutler's other invaluable insight that most experts overlook is that you have to use the chelators on a schedule that actually allows them to remove mercury from the body. This requires taking lipoic acid on a 3 hour schedule to maintain relatively constant levels of lipoic acid in the body. (If it takes, say, 12 hours to move a mercury atom from the brain to the feces, and lipoic acid has a half-life on the order of 6 hours, taking lipoic acid every other day is useless.)
Cutler is qualified to write on the subject; not only does he have a PhD in biochemistry from Princeton, he also writes that he overcame an amalgam intoxication. When your own skin is on the line, you become very meticulous. I was deeply, deeply skeptical of Cutler's claims which lie far outside of mainstream medical scripture; it wasn't until I had corresponded with scientists who had spent years of their lives researching amalgam toxicity that I concluded that his claims are true. I myself have followed his advice, my health improved significantly.
In my informed opinion, this is the gold standard of treatment for mercury intoxications; more than a few people report that they had tried sundry remedies, but it was not until they got serious with Cutler's treatment that they began to recover. It may be worth mentioning Cutler's subsequent book, Hair Elements, which offers a better understanding of Cutler's thinking and results on some aspects of this subject. A caveat: prepare for a somewhat disjointed book that has never met a professional editor.
Some books deserve 5 stars, this book would easily deserve 12 or more. Allow me to note that the Nobel Prize has been awarded for smaller innovations.