Adrian Mole is 39 and a quarter. Unable to afford the mortgage on his riverside apartment, he has been forced to move into a semi-detached converted pigsty next door to his parents, George and Pauline. His ravishing wife Daisy loathes the countryside, longs for Dean Street and has yet to buy a pair of Wellingtons; they are both aware the passion has gone out of their marriage, but neither knows how to reignite the flame. To cap it all off, Adrian is leaving his bed numerous times a night to go to the lavatory and has other alarming symptoms, leading him to suspect prostate trouble.
Meanwhile, his mother thinks that an appearance on the Jeremy Kyle show might solve the mystery of her daughter's paternity once and for all. And when George is asked to provide a DNA sample, will the shock kill him? He is already disabled, though still chain smoking and has had an ashtray welded onto the arm of his wheelchair.
As Adrian's worries multiply, a phone call to his old flame Dr Pandora Braithwaite, BA, MA, PhD, MP and Junior Minister in the Foreign Office, ignites memories of a shared passion and makes him wonder - is she the only one who can save him now?