Platform: Xbox 360 | Edition: Standard Edition
A few other things that Alex also learns quickly is that he is not alone in possessing amazing abilities, that there is a secret war brewing in New York City and he is on its front lines. A deadly infection has spilled out of control and the government has seized the media to stop the spread of information and has placed New York under quarantine as martial law is instated; igniting a firestorm of combat, carnage and death. As he roams the city, he faces an ever growing army of infected creatures warped and changed by the virus. As it spreads, the virus overwrites the genetics of those it infects, warping and changing their form into something else, something that seems to have been planned. The answers he seeks appear to be tied to the virus, so he rushes to discover the truth behind it, but standing against him and his goal is Project Blackwatch. An elite army specialist force, they are tasked with halting the spread of the virus at any cost and are eager to bring Alex in dead or alive to determine his connection to it. It would seem that they are potentially both enemy and ally to Alex's cause. Will Alex assist Blackwatch in its hunt, or join forces with the virus and subjugate humanity, pushing his powers to the limit as the genetic shackles of humanity fall by the wayside? That choice is up to the player in Prototype.
In Prototype players engage in 'Deceive or Destroy' gameplay. This allows gamers the choice to either blend in with the population and covertly progress through the story, or fully unleash Alex’s powers, and move through New York City like a walking slaughterhouse, taking control of military vehicles, and causing destruction at every turn.
Although Alex is literally strong enough to fling people and large objects around easily, his most intriguing power is his ability to 'consume' people. In doing this he acquires their memories, abilities, and their appearance. New memories help him to solve the mystery of how he got the way he is, while new appearances allow him to shape-shift into new useful forms at will and abilities allow him to manoeuvre in parts of the game requiring specific skills in specific situations. In addition, Alex's consumption of people also facilitates his ability to transform his physical body and manipulate his senses. Most weapons acquired in this way are outgrowths from his appendages like exaggerated blades, shields, whips and claws used for brutal close combat, but consumption also allows for powerful abilities like thermal vision, which provides for vision through smoke and obstacles, as well as 'infected vision' with which Alex can detect hotspots of viral infection throughout the city.