50/50 is a great film that masterfully mixes some genuine laughs together with some truly touching moments. As other reviews have stated, this film is about a young man's struggle with cancer.
What makes this film stand out for me personally was not the comedic elements, but the poignant heartfelt moments, such as when he tells his mother. It was these scenes that I truly appreciated, and it was done well as I was very much able to empathise. Gordon Levitt should also be commended for putting in a wonderful performance.
At times however, I felt the pace was a bit slow and Seth Rogen's character could have been better portrayed by a less stereotypical actor.
In summary however, if you want a great drama, with the occasional laugh, I highly recommend this film.