I'd never heard of 2600 before I found it on the Kindle store and subscribed.
As someone who has been working with computers (as a hobby and now professionally) since I was about 5 years old, I find it fascinating. There are some articles which aren't any interest to me (like any magazine) and there are some that are very interesting - mainly in terms of how things work and how I can look to protect the systems that I work with from outside attacks.
One thing to point out, though, is that if you subscribe, the copy provided as a subscription is DRM'd, but I think that individual copies are not. Not quite sure that I'm happy about that, but that's the way that Amazon work, it seems.