I remember reading 100% when it was on initial release back in 2002/3, and I was never able to get hold of the last issue - and the initial TPB was equally impossible to get hold of. As a result, this release is a godsend to me, as I finally find out how it ends!
The first things you'll notice is the monochrome art style, with its bold black lines that fit in with the book's vision of NYC in 2038. The second is how it's presented as an actual novel (albeit with images instead of words as the driving force), broken down into chapters instead of being issue-by-issue. Indeed, this is how the comic was presented, but in that case they had a cover on each side.
The vision of NYC 2038 is also straight from the pages of George Foy, where now both pole dancing and boxing are accompanied by projections of the participants' innards sloshing about above the arena - but, like Blade Runner, on street level you couldn't tell the difference between then the present-day, barring a few fashion choices. Indeed, it isn't Pope's intention to explore this world, as it follows the lives of various people who live there.
The storylines are all, as Pope explains, all about one thing: it's three inter-related love stories, which just happen to be taking place thirty-odd years into the future, where the world seems to have gotten a lot trashier than it currently is. There's Daisy/Dollar Bill, a gastro dancer (see above...) and busboy John, Strel and her gastro boxing ex-husband Haitous, and lastly Kim and Strel's cousin/kettle-centric artist Elroy. So whilst the future may be seen as a chaotic place, the book focuses on the humanity that lives there.
The characters are all likeable, even though they all have their flaws worn on their sleeve and they draw you into the world, so although it does sound a tad pompous, the novel comparisons do stand up because you are going to turn the pages not to look at the next bit of artwork, but for the next piece of dialogue.
However, it is a shame they didn't reproduce the comic's original covers within the pages of the TPB, because they too were works of art - and would five extra pages really have broken the bank at DC Vertigo?
Either way, if you want a TPB that rises above those lined up for a Hollywood defilement and doesn't weigh half a ton, this is a good place to start.